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Around the globe there are many ongoing and completed genome projects. We found dysregulation of mitochondrial activity, which was associated with excessive ROS formation and reduced mitochondrial membrane potential, and observed a synergistic effect for oxidative stress-mediated apoptosis in Stat3-KD cells or cells carrying Stat3 YFbut not Stat3 SDsuggesting the importance of functional mitochondrial Stat3 in this context. Data have been gathered for 64 patients, of whom 32 have some evidence of CNS abnormalities based mainly on MRI findingsand 32 do not have such evidence. Data, and the tools developed during this study, have been made publicly available as a resource for genomics in Sweden and abroad. These studies argue that the effect of DAF on autoimmunity is complex and may require multiple genetic elements. Ichthyin mRNA levels were shown to increase during keratinocyte differentiation in cells from healthy and affected individuals. SLCs were predominantly found in the absorption-responsible gut regions.